Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women, with impacts across the lifespan from adolescence to post menopause.

The inositol stereoisomers, myo-inositol (MI) and D-chiro-inositol (DCI), are the two most abundant members of a family of nine steroisomeric inositols and are found widely in nature. Inositols act as second messengers for insulin, and their deficiency contributes to the various features of PCOS. It is suggested that the inositols MI and DCI can reduce insulin resistance, improve ovarian function, and reduce androgen levels in women with PCOS. MI promotes glucose uptake and is also involved in follicle stimulating hormone (FSH) mediated pathways impacting proliferation and maturation of granulosa cells. Under the stimulus of insulin, MI is converted to D-chiro-inositol (DCI), which stimulates glycogen production and facilitates glucose uptake. It is proposed that hyperinsulinaemia in PCOS enhances ovarian epimerase activity which enhances DCI synthesis at the expense of MI concentration. MI is also postulated to enhance aromatase synthesis in granulosa cells and therefore reducing androgen production.

Insulin resistance in women with PCOS is associated with high plasma Homocysteine (Hcy). Furthermore, intense treatment for PCOS can influence homocysteine levels. Hyperhomocysteinemia has been highly associated with increased risk for cardiovascular disorders, such as, atherosclerosis, thromboembolism and dyslipidemia. The importance of vitamin B12 in the remethylation of Hcy to methionine is well recognized, and hyperhomocysteinaemia is a feature of vitamin B 12 deficiency. Moreover, plasma Hcy is a sensitive biomarker of folate deficiency thus demonstrating that folate plays also an important role in preclusion of the Hcy accumultaion. It has been previously demonstrated that folate and vitamin B12 treatment improved insulin resistance in patients with metabolic syndrome.

Melatonin (N-acetyl-5-methoxytryptamine) is secreted by the pineal gland. Some of the major functions of rhythmic secretion of melatonin in blood include regulation of sleep, modulation of circadian rhythms, and involvement in the body’s immune response. Melatonin is also a powerful endogenous antioxidant, and its supplementation has radical-scavenging and anti-inflammatory actions. Current evidence suggests the involvement of melatonin in ovarian physiology including ovulation, follicular development, luteal function, and oocyte maturation. Furthermore, melatonin deficiency seems to be involved in the pathophysiology of PCOS.

EVA INTIMA® OVASIL, thanks to its targeted formula and its documented action, improves the metabolic and hormonal profile of women with PCOS, contributing to the treatment of all its symptoms.

1 vial daily before bedtime or according to doctor’s advice.

DIRECTIONS FOR USE

Press the cap firmly until the powder falls into the solution. Shake the vial well until the powder is completely dissolved. Open the vial and drink the solution directly.

PRECAUTIONS

• Do not exceed the recommended daily dosage.
• Food supplements should not be used as a substitute for a balanced diet.
• The excessive consumption may produce laxative effect.
• This product is not intended for prevention, treatment or cure of human disease. Consult your doctor if you are pregnant, breastfeeding, under medication or having health problems.
• Store in a dry and cool (15-25oC) place, out of children’s reach.